The 11 Beta-HSD1 Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The 11 Beta-HSD1 Polyclonal Antibody has been validated for the following applications: EIA, Immunoassay, ELISA, Immunohistochemistry, and Western Blot.
Description
Hydroxysteroid 11-beta dehydrogenase 1 encoded by HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in HSD11B1 has been associated with obesity and insulin resistance in children. Mutations in HSD11B1 and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein